The Archaeological Museum of Florina began to be built in the 1960s to accept the ancient objects of traditions and meditations that had been housed in a shop of the city’s market. By 1970 the exhibition of the ground floor with works of sculpture had been completed in its three rooms, while the fourth hall and the first floor had until 1990 exhibits of pre-historic and Hellenistic ceramic displays.

In 1991, an exhibition of excavations from the Hellenistic cities of the area (Petres and Florina) was organized on the first floor of the Museum, while a section of the same storey was organized by the 11th Byzantine Antiquities Conservancy of Epirus, an exhibition of Byzantine antiquities. In 1998 the archaeological material was reissued with informative texts on the history of the Prefecture and with accompanying material, while major building improvements and restoration of chronic building problems were preceded. The inauguration of the new museum exhibition took place in May 1999.